Clavatadines C-E, Guanidine Alkaloids from the Australian Sponge Suberea clavata

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Buchanan, Malcolm S
Carroll, Anthony R
Wessling, Deborah
Jobling, Michael
Avery, Vicky M
Davis, Rohan A
Feng, Yunjiang
Hooper, John NA
Quinn, Ronald J
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2009
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Abstract

Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea claVata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.

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Journal of Natural Products

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72

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5

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Chemical sciences

Biological sciences

Biochemistry and cell biology not elsewhere classified

Biomedical and clinical sciences

Traditional, complementary and integrative medicine

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