Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas

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Lounnas, Nadia
Rosilio, Celia
Nebout, Marielle
Mary, Didier
Griessinger, Emmanuel
Neffati, Zouhour
Chiche, Johanna
Spits, Hergen
Hagenbeek, Thijs J
Asnafi, Vahid
Poulsen, Sally-Ann
Supuran, Claudiu T
Peyron, Jean-Francois
Imbert, Veronique
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2013
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Abstract

The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we obsd. for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacol. inhibition decreased cell proliferation and induced apoptosis. The same results were obsd. with the SupT1 human T cell lymphoma line. In addn. we obsd. an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.

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Cancer Letters

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333

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1

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Biologically active molecules

Oncology and carcinogenesis

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