Takotsubo cardiomyopathy (TTC) presents similarly to acute coronary syndrome and accounts for approximately 1–2% of all suspected cases of myocardial infarction (Akashi et al. Citation2008). It is characterised by transient systolic and diastolic left ventricular dysfunction with the absence of coronary occlusion (Ono and Falcão Citation2016). Reverse Takotsubo cardiomyopathy (rTTC) is a rare variant of TTC which has a distinct presentation characterised by basal and mid-wall segment hypokinesis or akinesis and apical hyperkinesis (Rosu et al. Citation2017). It typically affects older women and is triggered by emotional or physical stress. The pathophysiology of this condition is not well understood; however, several proposed causes include multivessel epicardial coronary artery spasm, coronary microvascular impairment and catecholamine cardiotoxicity (Akashi et al. Citation2008). Prognosis of this condition is generally favourable with full recovery of left ventricular function and in-hospital death rates ranging from 0 to 10% (Ono and Falcão Citation2016). Takotsubo cardiomyopathy has been associated with sepsis; however, there have been no reports of TTC related to septic miscarriage to our knowledge. We present a case of TTC associated with severe septic miscarriage.