Tolerability and Safety of Primaquine in Papua New Guinean Children 1 to 10 Years of Age
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Bassat, Quique
Kiniboro, Benson
Robinson, Leanne J.
Rosanas-Urgell, Anna
Stanisic, Danielle
Siba, Peter M.
Alonso, Pedro L.
Mueller, Ivo
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Abstract
Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age.
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Antimicrobial agents and Chemotherapy
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56
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4
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© 2012 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
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Microbiology
Medical microbiology
Pharmacology and pharmaceutical sciences