NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

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Wedlock, Louise E
Kilburn, Matt R
Liu, Rong
Shaw, Jeremy A
Berners-Price, Susan J
Farrell, Nicholas P
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2013
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Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

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Chemical Communications

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49

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62

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ARC

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DP1095383

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© 2013 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.

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Chemical sciences

Bioinorganic chemistry

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