In the coming decades cities around the world must face the imperative to transform in the face of critical and converging challenges, to ensure urban environments are liveable and functional as the global environment, economy and society change dramatically. This includes creating conditions conducive to decoupling urban life and prosperity from fossil-fuel consumption, reducing energy needs, maintaining and restoring biodiversity, mitigating against climate change impacts, and improving resource productivity. We propose that the next evolution in urban design will go beyond influencing behaviour, to directly and intentionally influencing the health and wellbeing of people living in cities. Integrating nature into cities can provide systemic environmental and economic improvements to cities, mitigating the impacts of climate change on these systems and often delaying, downsizing or negating the need for investment in conventional infrastructure. This chapter explores how we can use this spectrum of knowledge-areas to design cities that foster happy and healthy individuals; moving beyond cities for survival, to cities for life. We explore the history, theoretical basis and supporting research for biophilic urbanism, before considering the importance of applying this design approach across multiple scales of urban design and development, including the building, street and city scales. We then introduce a whole systems approach to urban greening based on a triad of the natural, operational and economic realms of urban nature. We present examples of systemic urban greening that exemplifies this approach, demonstrating how such ideas can indeed be applied and achieved today.