Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia
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Daley, D
Pang, S
Gottlieb, T
Merlino, J
Nimmo, GR
George, N
Korman, TM
Streitberg, R
Robson, J
Peachey, G
Collignon, P
Bradbury, S
Colombi, E
et al.
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Abstract
Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.
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International Journal of Antimicrobial Agents
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56
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4
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© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
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Mowlaboccus, S; Daley, D; Pang, S; Gottlieb, T; Merlino, J; Nimmo, GR; George, N; Korman, TM; Streitberg, R; Robson, J; Peachey, G; Collignon, P; Bradbury, S; Colombi, E; et al., Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia, International Journal of Antimicrobial Agents, 2020, 56 (4), pp. 106121